Epidemiology of Type 1 and Type 2 Diabetes Mellitus in Kazakhstan: Data from Unified National Electronic Health System 2014-2019

Abduzhappar Gaipov, Dinara Galiyeva, Arnur Gusmanov, Yesbolat Sakko, Alpamys Issanov, Kuralay K. Atageldiyeva, Kainar Kadyrzhanuly, Aiymzhan Nurpeissova, Marzhan Rakhimzhanova, Aigul Durmanova

1 more author

Antonio Sarría‐Santamera

2022

Full text Open access: Green Metadata (CSL-JSON)
DOI 10.21203/rs.3.rs-1432205/v1
Data confidence 70 medium
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Abstract

Abstract Background: We aimed to explore descriptive epidemiology of T1 and T2 Diabetes Mellitus (DM) and to investigate demographic factors and comorbidities associated with all-cause mortality by aggregating and utilizing large-scale administrative healthcare data from the Unified National Electronic Health System (UNEHS) for 2014-2019 years period.Methods: We used Kaplan-Meier and log-rank test to calculate failure function and differences in survival by age, sex, ethnicity, and comorbidities with all-cause mortality for Type 1 and Type 2 DM. Cox proportional hazards regression analysis was used to obtain crude and adjusted hazard ratios.Results: Prevalence of Type 1 and Type 2 DM increased 1.7 times from 2014 to 2019. Mortality of Type 1 and Type 2 DM also increased 4 times and 6 times from 2014 to 2019, respectively. Male sex, older age and Kazakh ethnicity were associated with a higher risk of all-cause death compared to females, younger age and other nationalities than Kazakh in patients with Type 1 and Type 2 DM. Coronary artery disease, diabetic nephropathy, stroke, amputations and neoplasms were associated with a higher risk of all-cause death. Conclusion: The prevalence and mortality rate of Type 1 and Type 2 DM increased during the years 2014 - 2019 in Kazakhstan. Male sex, older age and Kazakh ethnicity were associated with a higher risk of all-cause death compared to females, younger age and other nationalities than Kazakh. Coronary artery disease, diabetic nephropathy, stroke, amputations and neoplasms were associated with a higher risk of all-cause death.