A recent bottleneck of Y chromosome diversity coincides with a global change in culture

Monika Karmin, Lauri Saag, Mário Vicente, Melissa A. Wilson Sayres, Mari Järve, Ulvi Gerst Talas, Siiri Rootsi, Anne-Mai IlumäE, Reedik Mägi, Mario Mitt

90 more authors

Luca Pagani, Tarmo Puurand, Zuzana Faltyskova, Florian Clemente, Alexia Cardona, Ene Metspalu, Hovhannes Sahakyan, Bayazit Yunusbayev, Georgi Hudjashov, Michael DeGiorgio, Eva‐Liis Loogväli, Christina A. Eichstaedt, Mikk Eelmets, Gyaneshwer Chaubey, Kristiina Tambets, Sergei Litvinov, Maru Mormina, Yali Xue, Qasim Ayub, G. Zoraqi, Thorfinn Sand Korneliussen, Farida Akhatova, Joseph Lachance, Sarah A. Tishkoff, Kuvat T. Momynaliev, François‐Xavier Ricaut, Pradiptajati Kusuma, Harilanto Razafindrazaka, Denis Pierron, Murray P. Cox, Gazi Nurun Nahar Sultana, Rane Willerslev, Craig Muller, Michael Westaway, David Martin Lambert, Vedrana Škaro, Lejla Kovačević, Shahlo U. Turdikulova, Dalimova Dilbar Akbarovna, Rita Igorevna Khusainova, Natalya Trofimova, Vnira R. Akhmetova, Irina M. Khidiyatova, Daria V. Lichman, Jainagul Tolonovna Isakova, Elvira Pocheshkhova, Zhaxylyk M. Sabitov, Барашков Николай Алексеевич, Pagbajabyn Nymadawa, Evelin Mihailov, Joseph Wee Tien Seng, Irina Evseeva, Andrea Bamberg Migliano, Syafiq Abdullah, George Andriadze, Dragan Primorac, Л. А. Атраментова, Olga Utevska, Levon Yepiskoposyan, Damir Marjanović, Alena Kushniarevich, Doron M. Behar, Christian Gilissen, Lisenka E.L.M. Vissers, Joris Andre Veltman, Elena Vladimirovna Balanovska, Miroslava V Derenko, B. А. Malyarchuk, Andres Metspalu, Сардана Аркадьевна Федорова, Anders Eriksson, Andrea Manica, Fernando Luis Mendez, Tatiana M. Karafet, Krishna R. Veeramah, Neil N Bradman, Michael F. Hammer, Ludmila P. Osipova, Oleg Pavlovich Balanovsky, Э. К. Хуснутдинова, Knut Johnsen, Maido Remm, Mark Thomas, Chris Tyler‐Smith, Peter A. Underhill, Eske Willerslev, Rasmus Nielsen, Mait Metspalu, Richard Villems, Toomas Kivisild

2015

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DOI 10.1101/gr.186684.114
Data confidence 70 medium
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Abstract

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.