Abstract
Rumex tianschanicus L. is a medicinal plant used in folk medicine for diseases of the gastrointestinal tract, liver, diarrhea, constipation, and skin diseases [1,2]. Despite the widespread use of medicinal plants in traditional medicine, only a few of them have been tested for efficacy and safety [3]. In this regard, the purpose of this work was to evaluate the properties of biologically active complexes isolated from the roots and rhizomes of Rumex tianschanicus L. in the experience of chronic toxicity. Phytochemical analysis was carried out by HPLC. As a result of high-performance liquid chromatography (HPLC) analysis of the phytocomplex, its composition was established: 84.9% anthraquinone glycosides, 14.7% anthraquinone aglycones, 0.4% naphthaquinones. Animals of the experimental groups were administered Rumex tianschanicus L. extract orally at different doses of 10 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg for 21 days. The extract had no direct effect on the functions of the gastrointestinal tract and liver, which is confirmed by the results of hematological and biochemical blood tests in rats. Thus, the extract based on Rumex tianschanicus L. was found to be safe when administered orally and should be studied as a therapeutic agent.