Abstract
Relevance: Cutaneous leiomyosarcoma is a rare primary dermal neoplasm, accounting for up to 2-3% of all superficial sarcomas. It can occur at any age, most likely between the ages of 50 and 70 years. This tumor has a high recurrence potential in case of insufficiently deep excision. Recurrent tumors are more aggressive and characterized by subsequent metastasis. The purpose of the study was to demonstrate the results of the histopathological examination of a cutaneous leiomyosarcoma / atypical smooth muscle tumor. Results: Cutaneous leiomyosarcoma was represented by spindle-shaped cells with high cellularity located in bundles and growing expansively, surrounded by a capsule. The nuclei of the cells were elongated, hyperchromic. Cells with atypical abnormal nuclei were present in smaller quantities. The mitoses, including atypical, were numerous. IHC staining for SMA, Desmin, H-Caldesmon – diffusely positive on tumor cells. The reaction for S100, Myogenin – negative. Conclusion: A cutaneous leiomyosarcoma can be finally diagnosed only after a pathomorphological examination of the specimen and differential diagnostics using additional research methods.