Platelet-rich autoplasma effect on intestinal anastomosis regeneration in rabbits

Berik Dzhumabekov, А.Т. ДЖУМАБЕКОВ, Dzhumagaly Kazybaevich-Ismailov, Т. А. Байтилеуов, Ildar Ravisovich Fakhradiyev

Archives of the Balkan Medical Union, 2019

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DOI 10.31688/abmu.2019.54.4.02
Data confidence 85 high
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Abstract

L'effet de l'auto-plasma riche en plaquettes sur la régénération de l'anastomose intestinale chez le lapinIntroduction.La régénération de la plaie est un processus important dans les pratiques chirurgicales.Cependant, l'échec d'une anastomose intestinale reste un problème de chirurgie intestinale.L'objectif de l'étude.Évaluer l'effet du plasma riche en plaquettes (PRP) et comparer l'efficacité de différentes méthodes d'application dans la régénération de l'anastomose intestinale chez le lapin.Méthodes.Un auto-plasma riche en plaquettes a été obtenu chez 81 lapins, qui ont été utilisés pour étudier deux méthodes d'application de PRP (injection dans la couche musculaire / immersion dans la paroi intestinale) par rapport au groupe témoin sur l'anastomose de bout en bout de l'intestin grêle. .Résultats.L'analyse des données histologiques et morphométriques de l'étude a montré que la régénération entre les échantillons d'anastomose intestinale traités avec du trempage au PRP et les injections dans la ABSTRACT Introduction.Wound regeneration is an important process in surgical interventions.Failure of an intestinal anastomosis is an important intestinal surgery problem.The objective of the study.To evaluate the effect of platelet-rich plasma (PRP) and compare the effectiveness of various application methods in intestinal anastomosis regeneration in rabbits.Methods.Platelet-rich auto-plasma was obtained from 81 rabbits, which was used to study two methods of applying PRP (injection into the muscle layer / soaking in the intestinal wall) in comparison with the control group, on the end-to-end small-intestinal anastomosis.Results.The analysis of the histological and morphometric data showed that the regeneration between the samples of intestinal anastomosis treated with PRP soaking and injections into the intestinal wall is more favorable in comparison with the control group, which, in turn, was determined by the quantitative ratio of inflammatory infiltrate, fibroblast proliferation, neo-angiogenesis, and collagen deposition.PRP