Solving the Reverse Problems of Pharmacokinetics for a Linear Two-Compartment Model with Absorption

Baydaulet A. Urmashev, A. T. Tursynbay, Almas Temirbekov, Aidana B. Amantayeva

2018

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DOI 10.1109/icaict.2018.8747019
Data confidence 70 medium
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Abstract

A new method is proposed for revealing the nonuniqueness of the solution of the inverse problem. The existence of three solutions of this equation is analytically proved and an algorithm for their finding is presented. The obtained results indicate the ambiguity of solutions of inverse problems and the obtained sets of parameters of the corresponding numerical methods for solving inverse problems of pharmacokinetics require additional conditions for determining the necessary set of pharmacokinetic parameters.