Genetic toxicology and genetically active environmental factors

2018

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.26577/ijbch-2018-2-343
Data confidence 85 high
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Anthropogenic impact on the environment, including, but not limited to water and soil contamination with oil and xenobiotics, causes cytotoxic, mutagenic and carcinogenic effects, and nowadays is considered the main negative factor of genetic alterations in living populations. In examinations of mutation processes in populations, inhabiting at ecologically unfavorable areas, high frequency of dominant mutations that alter normal growth inside uterus, causes development glitches in newborns, or even stillbirth. Such data is conditioned by direct dependence between the intensity of environmental pollution and impairment of ecologically effected genetic situation. Assessment of genotoxicity can be provided through specific tests, indicating degree of mutagenic effect and probability of its manifestation. Nevertheless, even living organisms, such as plants, suffering from environmental pollution, can produce chemical compounds that induce genotoxicity. Medicinal substances isolated from these plants are not exception as well. An attempt to provide analysis of genotoxicity implementation and importance of investigations performed in this field is presented in this paper.