Antifungal prenylated isoflavonoids from Maclura aurantiaca

Y Orazbekov, Ubaidilla Datkhayev, Manas T. Omyrzakov, Ahmed M. Metwaly, B Makhatov, MR Jacob, Baizanat A Ramazanova, Zuriyadda Sakipova, A Azembayev, K Orazbekuly

2 more authors

К.К. Орынбасарова, S ARoss

2015

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DOI 10.1055/s-0035-1556218

Data confidence 85 high

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Abstract

Three prenylated isoflavonoids ( 1 – 3 ) have been isolated from the ethanolic extract of Maclura aurantiaca fruits. The isolated compounds were chemically identified as 3'-hydroxyeuchrenone ( 1 ), euchrenone ( 2 ), 5,3',4'-trihydroxy-6-(3-methylbut-2-en-1-yl) isoflavone ( 3 ). Compounds 1 and 2 showed antifungal activities against Candida glabrata with IC 50 values of 5.7 µg/ml and 1.0 µg/ml, respectively. Compound 3 showed antifungal activities against Cryptococcus neofomans and Candida glabrata with IC 50 values of 5.0 µg/ml and 4.9 µg/ml, respectively.