Abstract
Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggestdrawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involvesconsiderable technological difficulties: water predistillation under vacuum and also the dry sodium phenolategetting very hygroscopic. It is therefore of interest to look for more convenient alternative pathwaysfor the synthesis of salicylic acid, excluding the use of sodium phenolate and this drawback is eliminatedby using sodium and potassium salts of ethyl carbonic acid as carboxylation body. Consequently, accordingto the more convenient method we obtained the salicylic acid. In medicine, 1% solution of salicylic acidin 70 % alcohol called salicylic alcohol is used as an antiseptic. We investigated the antimicrobial activityof a 1% solution of salicylic acid in various concentrations of ethanol (40%, 50%, 60%, 70%, 80% and90%) in order to determine the effect of different concentrations of ethanol on the antimicrobial activity ofsalicylic acid. The experiment proved that 1% solution of salicylic acid in various concentrations of ethanol(40-90%) to the appropriate strains of bacteria acts with the same activity regardless of the concentration ofethanol (40%, 50%, 60%, 70%, 80% and 90%). These actions of the acid are due to its solubility in alcoholsof different concentrations and complete disintegration of salicylic acid molecules into ions. Thus, on thebasis of antimicrobial research the necessity of preparation of 1% solution of salicylic acid in 40% alcoholis proved as the drug is cheaper and cost-effective to produce. The technology of the new composition ofthe drug “Azisal” consisting of 0.25 g azithromycin and 1.0 g salicylic acid in 60% ethanol was developed,in a similar way solution of azithromycin in different concentrations 0.25, 0.5, 0.75, 1.0% in 60% ethanolwere prepared and their antimicrobial activities were defined. The comparison of their antimicrobial activityshows the effectiveness of the composite product called “Azisal”.