Phytochemistry And Pharmacological Activities Of Safflower Carthamus Tinctorius L.

Aknur Turgumbayeva, Г.О. Устенова, KD Rakhimov, Samir Anis Ross

2016

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DOI 10.1055/s-0036-1578782
Data confidence 85 high
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Abstract

Safflower, Carthamus tinctorius L., is a member of the family Compositae or Asteraceae, cultivated mainly for its seed, which is used as edible oil and as birdseed [1]. The chemical composition of a volatile oils obtained from air-dried flowers of C. tinctorius L. growing in Kazakhstan was determined. The oil was analyzed by GC-FID. 11 compounds were identified in the oil. The volatile oil was evaluated for its in vitro antimicrobial, antimalarial and antileishmanial. This is the first report on biological activity of complex from safflower flowers grown in Kazakhstan. An ointment of essential oil the from safflower flowers grown in Kazakhstan: for creating ointment of flowers safflower C. tinctorius L . optimum composition of the excipients. The most efficient composition of the technological parameters was ointment base with the following composition: essential oil obtained from the flowers of safflower 9.0 g., sunflower oil 40 ml. T-2 5 g., purified water 46.8 ml. Oleum Menthae piperitae 0.2 ml. Obtained an experimental industrial series of ointment based medical plant C. tinctorius L . Studies in animals (rabbits, guinea pigs, white rats) show harmlessness and good tolerability. Results of the experiments showed no pathological changes in the nature of general and specific indicators over the entire study period. Animals in all groups remained active and the complete experimental details of this study will be disclosed. Acknowledgement: The author, Turgumbayeva A.A is thankful to the Kazakhstan Government for three month scholarship for working under Dr. Samir A Ross, National Center for Natural Product Research, University of Mississippi, USA. References . [1] Li Dajue and Hans-Henning Mündel. 1996. Safflower. Carthamus tinctorius L. Promoting the conservation and use of underutilized and neglected crops. 7. P. 8 – 9.