Synthesis of 2-(4-chlorobenzylamino)-1-(4-nitrophenyl)ethanol and its chemical transformations

2008

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DOI 10.1134/s107036320812013x
Data confidence 70 medium
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Abstract

By the ring cleavage of p -nitrophenyloxirane with p -chlorobenzylamine the corresponding chlorobenzyl- and nitrophenyl-substituted aminoethanol was obtained that was brought into reactions of glycosylation, reduction and substitution aimed at the preparation and designing of new structures containing pharmacalogically active functional groups. Among the synthesized compounds a compound is revealed possessing moderately expressed antibacterial and antifungal activity.