On the problem of differential diagnosis in the detection of antineutrophil cytoplasmic antibodies

Olga Nikolayevna Egorova, Г. М. Тарасова, Б. Г. Исаева, A. V. Datsina, D. S. Dilmanova, S. Issayeva, M.G. Nogayeva, A. G. Issaeva, A. Amanzholova, M. M. Saparbayeva

2 more authors

A.A. Atasheva, A. B. Kanapina

Modern Rheumatology Journal, 2024

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.14412/1996-7012-2024-2-7-15

Data confidence 70 medium

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Abstract

Vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA) are a group of systemic autoimmune diseases characterized by necrotizing lesions of the walls of predominantly small vessels and the presence of ANCA against proteinase 3 or myeloperoxidase. However, an increase in ANCA levels can also be observed in other diseases, including autoimmune, malignant and infectious diseases, which complicates the interpretation of clinical and laboratory data and requires a differential diagnosis.