Abstract
The urgent search for new natural bioactive compounds has led to the investigation of freshwater microalgae in the Almaty region for their antibacterial properties. For this purpose, a study was carried out to investigate microalgae cultures from the division of Clorophyta for their potential to produce biologically active compounds (Parachlorella kessleri, Monoraphidium griffithii, Ankistrodesmus falcatus, Nephrochlamys subsolitaria), which also have the potential for wide use in other biotechnological applications. Methanol extracts of 4 strains of microalgae cultures against 11 strains of bacteria were used to evaluate the biological antibacterial activity. Significant antibacterial effects were observed, in particular the methanol extract of P. kessleri showed high activity against B. subtilis, S. aureus and K. pneumoniae; N. subsolitaria showed strong activity against B. subtilis, P. aeruginosa and E. coli. The results of GC/MS analysis confirmed the presence of important bioactive compounds (decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, hexamethylcyclotrisiloxane) in the microalgae extracts. The data obtained play an important role in the development of microalgae-based antibacterial drugs.