The effect of some pesticides on lipid peroxidation and on the content of cytochrome p-450 of mitochondrial membranes and liver microsomes of pregnant rats and their embryos

Dilfuza Tuychieva, Parida Mirkhamidova, Gulnara Abdullaevna Shakhmurova, K.A. Zhumagulova

E3S Web of Conferences, 2023

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1051/e3sconf/202345201017

Data confidence 70 medium

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Abstract

The article presents data obtained in experimental studies on the effect of pesticides - butylcaptax and droppa on lipid peroxidation of mitochondrial membranes and microsomes of liver cells of pregnant rats and their embryos. It has been shown that inoculation with pesticides intensifies NADP.H- and ascorbate-dependent LPO both in mitochondria and in liver microsomes of pregnant rats and their embryos. The level of MDA is higher in case of poisoning with butylcaptax on the 3rd day of pregnancy. A decrease in the content of the microsomal enzyme P-450 in the microsomal fraction of the liver of pregnant rats was also found with the introduction of butylcaptax and dropp. This decrease is more pronounced on butylcaptax poisoning on the 3rd and 19th days of pregnancy.