ASSOCIATION OF NATURAL KILLER CELLS ACTIVITY WITH THE INCIDENCE OF COLORECTAL NEOPLASIA AT SCREENING

Jandos Amankulov

2022

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DOI 10.52532/2521-6414-2022-2-64-14-18
Data confidence 70 medium
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Abstract

Relevance: Increased natural killer cell (NK cells) activity reduces colorectal cancer (CRC) risk. Previously published studies examined the association of NK cells and CRC prevalence in individuals at high cancer risk. The study aimed to study the relationship between NK cell activity and the incidence of advanced adenomas (AA) and CRC in a population with average cancer risk. Methods: The activity of NK cells was assessed by enzyme immunoassay (ELISA) of blood in participants of average risk with a measurement range of 25-2500 pg/mL. The level of NK cells below 200 pg/mL was defined as pathological. The informativeness of the diagnostic test for determining NK cell activity was assessed using indicators such as sensitivity, specificity, negative and positive predictive value, and clinical utility index. The probability coefficient for the development of colorectal cancer was calculated using logistic regression. Results: NK cell activity was assessed in 354 persons of average risk (mean age – 59 years; 36% men). The diagnostic accuracy of NK cells determination for CRC and AA was 76% and 72%, respectively, and the negative predictive value was 96%. The NK cell test demonstrated a good negative clinical utility index for CRC and AA (0.66 and 0.74, respectively). Individuals with low NK cell levels were seven times more likely to be diagnosed with CRC (95% CI 2.3-20.3; p<0.001). NK cell levels were higher in men compared to women (549 pg/mL vs 500 pg/mL) and lower in smokers (412 pg/mL versus 544 pg/mL), non-athletic participants (413 pg/mL versus 654 pg/mL), in people who abuse alcohol (389 pg/ml versus 476 pg/ml). Conclusion: Our study shows that a high level of NK cells can potentially exclude CRC and AA in individuals with average cancer risk