Supramolecular inclusion complexes of functionally substituted N-benzylidene-and allylidene-isonicotinohydrazides with oligosaccharides and their properties

nstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Serik D. Fazylov, О.А. Nurkenov, nstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, A.Zh. Mukasheva, Т. М. Сейлханов, Zarina Shulgau, A.M. Zhanzhuman

2020

Closed access Metadata (CSL-JSON)
DOI 10.31489/2020ch2/22-34
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Supramolecular inclusion complexes of functionally substituted N-benzylideneand allylidene-isonicotinohydrazides with oligosaccharides and their propertiesThis paper presents the results of a study of the synthesis and structural features of supramolecular inclusion complexes of N-benzylidene-and allylidene-isonicotinohydrazides with cyclic oligosaccharides (with βand 2-hydroxypropyl-β-cyclodextrins).The results of studying the synthesis and structural features of supramolecular inclusion complexes of N-benzylidene and allylideneisonicotinohydrazides with cyclic oligosaccharides (β-and 2-hydroxypropyl-β-cyclodextrins) are presented.The structure of the obtained supramolecular inclusion complexes was studied using one-dimensional 1 H, 13 C and DEPT NMR and two-dimensional spectroscopy of COSY ( 1 H-1 H), HMQC ( 1 H-13 C) and TOCSY ( 1 H-1 H).The formation of supramolecular inclusion complexes was established on the basis of changes in the chemical shifts of the NMR of the substrate and receptor atoms.Based on the analysis of spectral data, the proposed schemes of the obtained supramolecular inclusion complexes are presented.It was found that the interaction of the studied hydrazone substrates with cyclodextrins forms inclusion complexes 1:1 and 1:2 with the entry of the substrate molecule into the internal cavity of the receptor.The resulting products are able to dissolve in water or form stable aqueous dispersions.The antiradical effect of the synthesized supramolecular inclusion complexes with respect to the 2,2-diphenyl-1-picrylhydrazide radical was evaluated.Under the conditions of this test system, antiradical activity was detected in the supramolecular complex of N-(diethylamino)benzylidene-isonicotinohydrazide.The concentration of the complex was determined, capable of reducing the optical density of 100 μM of the test system solution by 50 %.