Abstract
BACKGROUND: After some clinical studies of the reproductive health of the female population of the Aral Sea region, we concluded that it is necessary to confirm by experiment the theory of the direct influence of dust-saline aerosols of the Aral Sea on the reproductive system of female individuals. AIM: The purpose of this work is to study the effect of dust-saline aerosols of the Aral Sea on the folliculogenesis process in rats at inhalation intoxication. METHODS: Inhalation in rats was carried out for 30 days for 4 hours a day for 5 days a week in special inoculating cylindrical chambers with the extra-chamber placement of animals in individual boxes and dynamic aerosol delivery. Morphological changes were assessed using electron microscopy. RESULTS: Ultrastructural changes in the ovaries of the experimental study group were characterised by the pathology of all structures of the cortical substance of the organ. The accumulation of lutein pigment, the utilisation of lipid inclusions and the destruction of the complete cell reflected the pathology of estrogen production-an important factor in the postovulatory phase of the ovarian cycle. CONCLUSIONS: Taking into account the proven effect of dust-saline aerosols on the production of estrogen, the violation of the postovulatory phase of the ovarian cycle, we trace the mechanism of folliculogenesis disturbance. This confirms the data of our previous studies on primary and secondary infertility in women living in the Aral Sea region and the necessity of creation and development of preventive measures for the inhabitants of the region.