Abstract
The article presents the results of cultivation of the laboratory strain of rabies virus in the cell cultures of BHK-21 and TN-KK49 in successive passages, which was carried out in different ways. In one case the passages was performed by transferring of infected cell cultures, in the other case - by introducing to the new batch of intact cells the suspension of infected cell cultures of the previous passage. It was established that both kinds of used cell culture are susceptible to rabies virus and it can be passaged in these substrates tested with these both ways. The cultural virus of the third passage preserves its pathogenicity with respect to mice at intracerebral infection.