MP395THE RESULTS OF NONINVASIVE BONE MINERAL DENSITY STUDIES IN CHILDREN AND ADULTS WITH END-STAGE RENAL FAILURE ON HEMODIALYSIS

Abay M. Shepetov, Gulnar Chingayeva, Б. А. Абеуова, Yerkebulan Karibayev, Makpal Kulkayeva, Karlygash Bayakova, Meyramgul Ohanova

2016

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DOI 10.1093/ndt/gfw190.52
Data confidence 70 medium
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Abstract

Introduction and Aims: Chronic kidney disease (CKD) is common and life-threatening condition in children and adults due to the development of end-stage renal disease (ESRD) and increased rate of cardiovascular mortality as well. The processes that cause disturbances of mineral bone metabolism and lead to bone diseases develop already in the early stages of CKD. These disorders correlate with CKD progression and they require special methods of examination. Methods: We report a prospective study examining the prevalence of reduced bone mineral density (BMD) in children and adults on hemodialysis. BMD was measured by dual-energy X-ray absorptiometry (DEXA) and quantitative ultrasound (QUS) in 33 children (4-18y.o.) and 28 adults (19-70y.o.) with ESRD. The duration of chronic hemodialysis (cHD) in children ranged from 1 to 74 months. Most of adult patients (86.4%) received cHD more than 12 months. The control group included 11 children with dialysis free CKD stage 3-4 (GFR - 15-29 ml / min). BMD of the hip (femoral neck) and lumbar spine (L2-L4) were investigated. Z-scores (number of standard deviations below the BMD) were reported in children. In adults along with Z-score, T-score (a deviation of peak bone mass) was reported as well and mean scores were calculated (0-1 intact; -1 - -2,5 osteopenia; -2,5 or less severe osteoporosis according to WHO osteoporotic range).