Biodegradation of Polymer Compounds Based on Cross-linked Dextranes

Klara Zenonovna Gumargalieva, O. V. Shipunova, Gennadii E Zaikov, Bulat A. Zhubanov, S. A. Moshkevitch

1995

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DOI 10.1080/00914039508028598
Data confidence 70 medium
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Abstract

Cross-linked dextranes can be used as the basis for drug storage consisting of a physiologically active polymer and the drug grafted to the polymer matrix. The drug storage form for medical treatment of infected centers of tuberculosis has been obtained. The kinetics of drug release into model media and blood plasma has been investigated. It was found that polymeric derivatives of isonyazide and kanamycin can be used for preparation of a low rate release and long time action drug storage.