Chemical transformations of N-morpholinylacetic acid hydrazide and steric structure of its derivatives

О. А. Нуркенов, Serik D. Fazylov, Ж. Б. Сатпаева, Ivan V. Kulakov, К. М. Турдыбеков, Dastan M. Turdybekov, S. A. Talipov, Bakhtiyar Tulyaganovich Ibragimov

2013

Closed access Metadata (CSL-JSON)

DOI 10.1134/s1070363213030183

Data confidence 70 medium

How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

The reaction of N -morpholinylacetic acid hydrazide with various isothiocyanates and potassium thiocyanate resulted in the corresponding potentially biologically active thiosemicarbazide derivatives. Potassium N′ -(2-morpholin-4-ylacetyl)hydrazinocarbothioate was synthesized and involved into heterocyclization in acidic environment to yield cyclic 5-(morpholinomethyl)-1,3,4-thiadiazole-2-thione. The structure of the synthesized compounds was established by IR, 1 H NMR spectroscopy, mass spectrometry, and XRD analysis.