Association of four genetic variants with colorectal cancer in Kazakhstan population

Yevgeniya Alexandrovna Kolesnikova, Dmitriy Babenko, Irina Kadyrova, Svetlana I. Kolesnichenko, Lyudmila Akhmaltdinova, Ilya Korshukov, Кабилдина Найля Амирбековна, Valentina Sirota, V. Zhumaliyeva, Dana Taizhanova

2 more authors

Dmitriy Vazenmiller, Anar Turmukhambetova

2021

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.18632/oncotarget.28070
Data confidence 70 medium
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Abstract

// Yevgeniya Kolesnikova 1 , Dmitriy Babenko 2 , Irina Kadyrova 3 , Svetlana Kolesnichenko 3 , Lyudmila Akhmaltdinova 3 , Ilya Korshukov 3 , Naylya Kabildina 4 , Valentina Sirota 4 , Vera Zhumaliyeva 4 , Dana Taizhanova 5 , Dmitriy Vazenmiller 6 and Anar Turmukhambetova 7 1 Department of Biomedicine, Karaganda Medical University, Karaganda 100008, Kazakhstan 2 Research and Scientific Center, Karaganda Medical University, Karaganda 100008, Kazakhstan 3 Shared Resource Laboratory, Karaganda Medical University, Karaganda 100008, Kazakhstan 4 Department of Oncology and Radiation Diagnostics, Karaganda Medical University, Karaganda 100008, Kazakhstan 5 Department of Internal Medicine, Karaganda Medical University, Karaganda 100008, Kazakhstan 6 Department of Obstetrics, Gynecology and Perinatology, Karaganda Medical University, Karaganda 100008, Kazakhstan 7 Department of Strategic Development and Science, Karaganda Medical University, Karaganda 100008, Kazakhstan Correspondence to: Ilya Korshukov, email: Korshukov@qmu.kz Keywords: colorectal adenocarcinoma; rs10795668; rs1035209; rs11190164; rs10506868 Received: July 03, 2021 Accepted: August 28, 2021 Published: October 12, 2021 Copyright: © 2021 Kolesnikova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05–1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18–2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17–2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37–0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population.