Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan

Timur S. Balmukhanov, A. K. Khanseitova, V. G. Nigmatova, А. S. Neupokoeva, D. A. Sharafutdinova, N. А. Аitkhozhinа

2015

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.4236/abcr.2015.44012

Data confidence 70 medium

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Abstract

Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.