Abstract
The work was carried out on the selection of probiotic microorganisms to create an environmentally friendly therapeutic and preventive biological product that is active against pathogens of agricultural animals. According to the results of research, 3 strains of lactic acid bacteria were selected for the construction of a probiotic - Lactobacillus plantarum 1, Streptococcus salivarius 20 n, Lactobacillus fermentum 15 showed the highest antagonistic activity against test cultures Salmonella typhimurium, Salmonella enteritidis, Salmonella gallinarum, Shigella flexneri 11, Shigella sonnei, Proteus vulgaris, Citrobacter sp., Edwardsiella sp., Yersinia sp., Escherichia coli and the ability to biosynthesize b vitamins (nicotinic acid, Inositol, cyanocobalamin), as well as the Propionibacterim shermanii strain, which showed antagonistic activity against 4 test cultures, namely, Salmonella typhimurium, Salmonella enteritidis, Salmonella gallinarum and Escherichia coli, which is a producer of vitamins nicotinic acid, Inositol and cyanocobalamin.