CLINICAL AND IMMUNOLOGICAL ASPECTS OF NEWBORN ADAPTATION BORN FROM MOTHERS WITH INTRAUTERINE INFECTION

Akmaral K. Zhumalina, Balash T. Tusupkaliev, Yuliya Zame, Lyudmila V VOLOSHINA, Klara B. Darzhanova

2020

Closed access Metadata (CSL-JSON)
DOI 10.52571/ptq.v17.n34.2020.680_p34_pgs_656_666.pdf
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Today about 40 % of babies are infected with intrauterine infections. The immune statuses of children during the neonatal period are largely associated with the patterns of pregnancies in their mothers. This work aimed to study clinical and immunological features in newborns of mothers with intrauterine infection. 48 infants were observed. Neonates were divided into two groups: group 1 – 33 newborns from mothers infected with cytomegalovirus infection, group 2 – 15 children from healthy mothers. The diagnosis of intrauterine infection verifizierung the basis of survey questionnaire for pregnant women, outpatient data of pregnant women and neonates, serologic study, PCR, ELISA, and the cellular immunity and humoral immunity. Somatic and obstetric and gynecological history of mothers was thoroughly collected and the risk factors for the development of complications in the early period of adaptation were assessed. The result of the study revealed that the structure of risk factors in pregnant women with intrauterine infections is of great importance the age of 30 years, genital and extragenital pathology during pregnancy, spontaneous abortions and non-developing pregnancy, abortion. Associated viral infections (CMV, Cytomegalovirus) predominate in the structure of congenital infection. The analysis indicates significantly burdened perinatal anamnesis in children infectious factors and factors of perinatal hypoxia. The leading clinical symptoms for intrauterine infections among the examined children are in the early neonatal period prematurity asphyxia, urinary symptoms, late neonatal period differ polymorphism symptomatic. In this period reveals a specific organ of the Central nervous system. In newborns with intrauterine infections observed inhibition of immunological indicators (CD4+, Cd8+, Cd 19+).