Abstract
Abctract: Тhis work presents thе results of research on the development of technologies bilayer suppositories new drug of combined action with the use of a thick extract of licorice and paracetamol.The optimal composition with use of hydrophobic and hydrophilic bases for double layer suppositories is selected.Suppositories are produced by pouring in split form.Given that carbon dioxide content of the extract was 5.0% by weight of the suppository, rational methods should be considered as a preliminary preparation of the concentrate.By dissolving the active ingredients in the part of molten basis.To assess the quality of the dosage form the investigation in accordance with the Pharmacopoeia Kazakhstan were performed.In operation conducted structural and mechanical properties rectal dosage forms which have a significant influence on their consumers, biopharmaceutical characteristics and play a determining role in the selection process parameters dosing suppository mass, speed and mixing time in the manufacturing process.The main physical and chemical indicators, and their standardization was done.Bilayer suppositories are smooth uniform surface, torpedo shape, oily to the touch.The double layer suppositories obtained in the longitudinal section of the outer layer visible brownish -yellow color and an inner layer of white color with a cream shade.The advantage of the developed dosage form as opposed to the analogue is the ability to use two kinds of actions-it is carbon dioxide extract of licorice and paracetamol, which will provide a wide range of pharmacological activity on the body and will demonstrate the combined effect.