A New Prenylated Isoflavonoid From Limonium leptophyllum

Asset Dizamatova, Kamila Zhumanova, Galiya E. Zhusupova, Aizhan I. Zhussupova, Radhakrishnan Srivedavyasasri, Mohamed A. Ibrahim, Samir Anis Ross

2019

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DOI 10.1177/1934578x19844137

Data confidence 70 medium

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Abstract

Phytochemical investigation of methanolic extract of Limonium leptophyllum (Plumbaginaceae), led to the isolation of 1 new isoflavonoid with a rare 5-membered dihydrofuran ring (1, leptoisoflavone A) and 8 known compounds. The known isolated compounds were identified as euchrenone b 9 (2), auriculasin (3), kaempferol (4), avicularoside (5), myricetin-3-arabinoside (6), trans-N-feruloyltyramine (7), trans-N-caffeoyltyramine (8), and β-sitosterol (9). The crude methanolic extract exhibited moderate activity toward endocannabinoid receptors. Auriculasin (3) showed activity toward cannabinoid receptor type 1 (86.7% displacement with IC 50 8.92 μM).