Preparation, characterization and investigation of in vitro release of anti-tuberculosis drug p-amino salicylic acid based on human serum albumin

Meiram Zh. Burkeev, Kreuter, Tazhbayev, Zhaparova, Tolkyn S. Zhumagalieva, Arystanova, Mukhanova

2017

Closed access Metadata (CSL-JSON)
DOI 10.31489/2017ch3/38-44
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Preparation, characterization and investigation of in vitro release of anti-tuberculosis drug p-amino salicylic acid based on human serum albuminNowadays the task of pharmaceutical chemistry is not only the search of the new drug preparations, but also the increase of the effectiveness of the latter by chemical modification or creation of new forms.With the aim of prolongation of the effect and decrease of single dose the possibility of immobilization of anti-tuberculosis drug p-amino salicylic acid (PASA) on human serum albumin (HSA) nanoparticles (NPs) by adsorption and incorporation methods was considered in this article.It is shown that independently of the immobilization method of the drug into polymer matrix the meanings of binding degree are very high.The study of the dependence of binding degree on drug concentration resulted in more than 95 % at maximum concentrations of the added drug.As it has been expected the drug release degrees have high meanings when incorporating as well as adsorption the drug on the surface of empty nanoparticles.They are 70 % and 80 % respectively.Therefore the results obtained allow us to hope on prolongation of the effect of p-amino salicylic acid and decrease of single dose of the drug in tuberculosis therapy.