Abstract
The paper presents the results of a study on the acute toxicity and cytotoxic activity of extracts from the aboveground part of Linaria vulgaris Mill., collected during the flowering phase in the steppe areas of the Bukhar-Zhyrau district of the Karaganda region (Republic of Kazakhstan). The extracts were obtained by maceration, percolation, and ultrasonic extraction using various organic solvents (ethanol, ethyl acetate, and chloroform). Acute toxicity was studied in outbred white mice weighing 18–25 g after a single intragastric administration at doses of 500, 1500, and 2500 mg/kg. Cytotoxic activity was assessed using the Artemia salina larvae lethality assay. The data obtained showed that the 70 % ethanol extract of Linaria vulgaris Mill. belongs to the category of practically non-toxic substances and is classified as low-toxic (toxicity class III). The study of cytotoxic activity demonstrated that the Linaria vulgaris Mill. extracts, regardless of the method of preparation or the extractants used, do not exhibit toxic effects against Artemia salina larvae. Thus, the studied extracts of the aboveground part of Linaria vulgaris Mill. are characterized by low toxicity and lack of cytotoxic activity, which indicates their potential safety and prospects for further biological and pharmacological studies.