Abstract
Central Asia faces mounting challenges from emerging infectious diseases, antimicrobial resistance, and food insecurity. This article examines regional cooperation in the One Health approach as a transformative strategy for strengthening regional health security through Regional Health Diplomacy (RHD). The Central Asia One Health Framework for Action represents a paradigmatic shift from fragmented national health strategies to an integrated regional approach. We argue that 'RHD' serves as the critical catalyst for implementing the One Health Framework. We call for the strategic implications to extend beyond health outcomes to encompass broader regional integration, establishing Central Asia as a pioneer in multi-sectoral health governance and a potential knowledge hub for One Health implementation.