New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties

Alexey Vladimirovich Trifonov, Nurbol Orynbasaruly Appazov, R. Kh. Bagautdinova, Lyudmila K. Kibardina, Michail A. Pudovik, Anna Pavlovna Lyubina, Alexandra D. Voloshina, Almir Sabirovich Gazizov, A. E. Tolegen, Nurila A. Togyzbayeva

5 more authors

Marat I. Syzdykbayev, Rakhymzhan Turmanov, Banu Diyarova, Elena Chugunova, Alexander Romanovich Burilov

2025

Closed access Metadata (CSL-JSON)

DOI 10.1134/s1070363225603369

Data confidence 85 high

How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Abstract As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.