Abstract
Hyperglycemia, characteristic of diabetes mellitus, contributes to the production of oxidative stress agents that cause impaired immune function and the development of a chronic inflammatory process. These factors underlie the development of late complications of diabetes mellitus, such as coronary heart disease, unstable angina pectoris, myocardial infarction, peripheral microangiopathy and other articular diseases that worsen the prognosis for diabetic foot syndrome. Inflammatory processes and disorders of the immune system contribute to an imbalance of tissue homeostasis, are associated with the appearance of chronic ulcers and the need for amputation of the lower extremities. The consequences of chronic wounds create an unfavorable reality of disability and mental stress for patients. Both patients and medical staff will undoubtedly benefit from a deeper understanding of the pathogenesis and pathophysiology of various non-healing ulcers. New knowledge was acquired by comparing the similarities between chronic wounds of different natures with their differences from acute wounds.