New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination

Alexey Vladimirovich Trifonov, Nurbol Orynbasaruly Appazov, R. Kh. Bagautdinova, Lyudmila K. Kibardina, Michael Arkad'evich Pudovik, Anna Pavlovna Lyubina, Alexandra D. Voloshina, Almir Sabirovich Gazizov, Aiym E. Tolegen, Nurila A. Togyzbayeva

4 more authors

Klara Kh. Darmagambet, Rakhymzhan Turmanov, Elena Chugunova, Alexander Romanovich Burilov

2025

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DOI 10.71267/mencom.7750
Data confidence 85 high
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Abstract

New phosphonium salts synthesized from 5-chloromethyl-8-methyl-7-azacoumarin-3-carboxamides and triphenylphosphine upon the Wittig reaction with aromatic aldehydes give the corresponding 5-styryl-7-azacoumarin derivatives. The cytotoxic activity of some phosphonium salts against cancer cell lines M-HeLa and HuTu-80 is equal to or superior to that of the reference 5-fluorouracil. The IC50 and SI values of the leading compounds exceed those for 5-fluorouracil by a factor of 3.7 and 2.2, respectively.