Piperidine-containing phosphonates as immunоcorrectors

Aigul Malmakova, Nurzhamal Kystaubayeva, T. Zharkinbek, M. Myrzakhanov, Marina K. Balabekova, V. К. Yu

2019

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DOI 10.1063/1.5117135
Data confidence 70 medium
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Abstract

The objective of Research is the target synthesis of azaheterocyclic systems as potential immunomodulators. Encouraging results had been obtained from the biotesting of structures combining the piperidine cycle and the phosphonate fragment in the molecule (where, R=alkoxyalkyl or arylalkyl, A=OH, Ph, fluorophenyl, heteterocyclic moiety, etc). Target piperidine-containing phosphonates (PP) are synthesized quite simply either by nucleophilic addition via the ketone group of piperidone or under the Kabachnik-Fields reaction conditions.