Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols

Zarina Shulgau, Yevgeniy Kamyshanskiy, Shynggys D. Sergazy, Aigerim Zhulikeyeva, Assel Urazbayeva, A. A. Makhmutova, Zhanybek Bokebaev, A.E. Gulyayev, Yerlan M. Ramankulov

2023

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.4067/s0717-95022023000601837

Data confidence 70 medium

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Abstract

The potential anti-inflammatory and antifibrotic activity of polyphenolic extracts of blueberry and grape was evaluated in a mouse model of lung damage induced by subcutaneous administration of bleomycin.The results of testing the polyphenolic extracts on two different systemic administration variants of bleomycin (intraperitoneal and subcutaneous) were compared.It was found that regardless of the method of bleomycin administration, indirect cross-acute and subacute damage to the pulmonary system was observed.Both patterns exhibited the same prevalence and severity.The administration of polyphenolic extracts of blueberry and grape to mice resulted in a significant decrease in theseverity of acute and subacute patterns of lung damage, suggesting their protective properties for the microcirculatory bed and a pronounced anti-inflammatory effect.