Abstract
Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Application of alloxan in experimental animals can cause Diabetes mellitus. The secondary metabolites of Etlingera elatior can be used as raw materials for diabetes mellitus drug. This study aims to determine the antidiabetic potential of ethanol extract of Etlingera elatior leaves by in vivo study. A total of 32 rats were divided into 6 groups, namely NC, DC, PC, DE1, DE2, and DE3. The results of data analysis using multivariate ANOVA on blood glucose level data every week showed p(0.000) < (0.05), and the results of data analysis using one way ANOVA on pancreatic β cell count data also showed that p(0.000) < (0.05). Etlingera elatior leaf ethanol extract has antidiabetic activity since it could reduce blood glucose levels and increase the number of pancreatic β beta cells through several mechanisms. The mechanism is triggered by phytochemical compounds contained in the leaf extract of Etlingera elatior.