A Novel Herbal Combination Decreased Lipid Droplets Accumulation and Cytokines Levels During Adipogenesis by Regulating Leptin, PPARγ and SREBP1c Genes Expression in 3T3L1 Cells

Vasavi Rakesh Gorantla, Srinivasa Rao Bolla, Sunanda Tuladhar, Muhammed Bishir, Arehally Marappa Mahalakshmi

2021

Closed access Metadata (CSL-JSON)
DOI 10.4103/ijnpnd.ijnpnd_88_20
Data confidence 85 high
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

The present study aims at demonstrating the anti-adipogenesis and anti-inflammatory of combination of extracts of commiphora wightti , curcuma longa, and tinospora cordifolia using mouse 3T3-L1 cells. Herbal formula (CCT) significantly suppressed the mRNA of PPARγ, leptin, and SREBP1c expression, which is reveals its significant anti-adipogenesis activity. In addition, CCT down-regulated TNFα and iNOS expression, this is an added advantage and helps to alleviate the inflammatory reactions during adipogenesis. These findings encourage for further studies using in vivo models of obesity and associated complications.