Anticancer Activity of Metformin: A Systematic Review of the Literature

Mohamad Aljofan, Dieter Riethmacher

Future Science OA, 2019

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.2144/fsoa-2019-0053
Data confidence 85 high
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Abstract

BACKGROUND: . However, the underlying mechanisms of metformin in the treatment of cancer are not fully understood. This systematic review aims to discuss the possible anticancer mechanism of action of metformin. METHOD: A search through different databases was conducted, including Medline and EMBASE. RESULTS: A total of 96 articles were identified of which 56 were removed for duplication and 24 were excluded after reviewing the title and abstract. A total of 12 research articles were included that describe different antiproliferative mechanisms that may contribute to the antineoplastic effects of metformin. CONCLUSION: This analysis discussed the potential anticancer activity of metformin and highlighted the importance of AMPK as a potential target for anticancer therapy.