Delivery of Probiotic to Microbiome by Layer-by-Layer Encapsulation

M. A. Abdulzhanova, Irina Savitskaya, Aida Kistaubayeva, Dina Shokatayeva, Alexander D. Pogrebnjak, Ludmila V. Ignatova, Aizhan B. Talipova

2019

Closed access Metadata (CSL-JSON)

DOI 10.1109/nap47236.2019.216929

Data confidence 85 high

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Abstract

The probiotic alginate microcapsules of a matrix type were obtained by extrusion method. The coating with an additional layer (layer-by-layer) was carried out by placing the alginate microcapsules with bacteria included in them in a 0.4% solution of chitosan or pullulan. Microcapsules look like spherical particles, white, with a smooth surface. The size of microcapsules is 102-145 microns. The efficiency of L. acidophilus AA-1 cells immobilization for uncoated (alginate) and coated with chitosan and pullulan microcapsules was 96.35±1.65; 95.28±2.31 and 94.43±2.31, respectively. The survival rate of strains encapsulated in alginate-chitosan and alginate-pullan under model gastrointestinal conditions in vitro increased on average by 50-70% compared with free cells.