Solid-Phase Microextraction for the Quantification of Acetophenone Migrated to Air and Water from Toys and School Supplies

Olga P. Ibragimova, Anara Omarova, Bauyrzhan Bukenov, Nassiba Baimatova

2023

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DOI 10.1134/s106193482310009x
Data confidence 85 high
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Abstract

Acetophenone is a reagent used in various consumer products, including fragrance chemicals in toys and childcare products. Contact with acetophenone-containing materials can harm human health, and therefore acetophenone migration levels should be controlled. A new procedure for the quantification of acetophenone migrated to air and water from toys and school supplies using solid-phase microextraction and gas chromatography with mass spectrometric detection is proposed. The optimal combination of acetophenone response and its relative standard deviations was achieved for air samples after 10-min extraction at 25°C and for water samples after the addition of 3.5 g of salt, agitation/preincubation at 500 rpm for 5 min at 60°C, and 20-min extraction by polydimethylsiloxane/divinylbenzene fiber. The developed procedure provided linear calibration with R2 > 0.996 at 1–50 µg/m3 in air and 1–20 µg/L in water, and low limits of detection and quantification of acetophenone in the air (0.01, 0.04 µg/m3) and water (0.01, 0.03 µg/L). Spike recoveries of acetophenone were 109–116% for air and 90–111% for water. Acetophenone concentrations migrated from toys and school supplies into the air ranged from 0.6 to 1.5 µg/m3, except for eraser type II (9.7 µg/m3) which exceeded the maximum permissible concentration by 3.2 times. Acetophenone concentrations migrated to water were 1.3–3.5 µg/L.