Antigenotoxic activity of biologically active substances from Inula britannica and Limonium gmelini

А. V. Lovinskaya, Saule Zh. Kolumbayeva, Tamara Minazhevna Shalakhmetova, М. В. Марсова, Serikbai K. Abilev

2017

Closed access Metadata (CSL-JSON)
DOI 10.1134/s1022795417120080
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

The antigenotoxic and antioxidant activities of biologically active substances of extracts from Inula britannica L. and Limonium gmelinii (Willd.) Kuntze in E. coli strains MG1655 (pColD- lux ), MG1655 (pSoxS- lux ), and MG1655 (pKatG- lux ) were studied by the bioluminescent test. Plant extracts from I. britannica and L. gmelinii in all used concentrations (0.5, 5.0, 50.0, and 500.0 μg/mL) had no genotoxic or oxidant activity. The extracts statistically significantly reduced the bioluminescence intensity of the pColD- lux , pKatG- lux , and pSoxS- lux sensors ( p < 0.05) induced by 4-NQO and dioxidine, hydrogen peroxide, and paraquat, respectively. The activity of the extracts depended on their concentration; the greatest antigenotoxic and antioxidant effects were detected at a concentration of 500.0 μg/mL.