Artificial genetic polymers against human pathologies

Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay Borisovich Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko, Nickolai A. Barlev

Biology Direct, 2022

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1186/s13062-022-00353-7

Data confidence 85 high

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Abstract

Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.