Synthesis and spatial structure of 4-(2-hydroxyethyl)-5-(2-hydroxyphenyl)-2H-1,2,4-triazolo-3(4H)-thione

A. S. Alimbayeva, О. А. Нуркенов, Alma Khassenovna Zhakina, Ivan V. Kulakov, Dastan M. Turdybekov, К. М. Турдыбеков

2009

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DOI 10.1134/s1070363209070226
Data confidence 70 medium
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Abstract

By reaction of 2-vinyloxyethyl isothiocyanate with salicylic acid hydrazide a synthesis of the corresponding thiosemicarbazide was performed. Alkaline hydrolysis of the latter led to an intramolecular heterocyclization into 1,2,4-triazole derivative. When cyclization was carried out in the water-alkali medium, 2-vinyloxyethyl fragment was shown to be hydrolyzed to form 4-(2-hydroxyethyl)-5-(2-hydroxyphenyl)-2 H -1,2,4-triazolo-3(4 H )-thione, whose spatial structure was established by XRD analysis.