Activation of Leukopoiesis in Rat Blood with Trimecaine‐Based Ionic Compounds

Lyailya Baktybayeva, V. К. Yu, Alexey Zazybin, Darya Zolotareva, Anuar Dauletbakov

2020

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DOI 10.1155/2020/7636290

Data confidence 70 medium

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Abstract

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.