Abstract
Aim: We researched frequency distribution of genotypes and alleles Lys198Asn of polymorphism of endothelin -1 gene associated with arterial hypertension development in Kazakh people Method: The research included 120 patients suffering arterial hypertension of 2-3 degree, average, high and very high degree of risk, and control group included 80 actually healthy person of Kazakh nationality. Result: The research discovered that development of arterial hypertension in the present ethnic group associated with polymorphism of endothelin-1 gene. Conclusion: At that, allele 198Asn and AsnAsn genotype of endothelin-1 gene act as marker of increased risk of arterial hypertension development.