Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock

A. BREIDABLIK, G. H. de Pater, C. WALTHER, Anna Nopp, A. B. Guttormsen

2012

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DOI 10.1111/j.1399-6576.2012.02732.x
Data confidence 70 medium
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Abstract

We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD-sens) and histamine release tests towards fluorescein. This is, to our knowledge, the first report where CD-sens has been used to aid in diagnosing an IgE-mediated anaphylactic shock caused by fluorescein.