Advanced Pain Management in Patients with Terminal Cancer

Kamilla Khojayeva, Mina Aubakirova, Dmitriy Viderman

2025

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DOI 10.2174/0109298673333227250106085952
Data confidence 70 medium
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Abstract

Understanding and managing pain in patients with terminal cancer is a vital aspect of palliative care, aimed at relieving suffering and improving quality of life in the final stages of illness. Studies indicate that approximately 50% of patients with stage 4 cancer report moderate to severe pain, with a quarter experiencing severe cancer-related pain. Despite opioid prescriptions in 97% of cases, a significant portion of patients continues to suffer unresolved pain during the last week of life. Cancer-related pain is multifaceted, often involving nociceptive, neuropathic, and mixed elements, necessitating a thorough, multidimensional approach to both assessment and treatment. The challenge of opioid tolerance and the potential for addiction demands careful monitoring. Interventional therapies, including nerve blocks and spinal cord stimulation, are gaining attention as valuable complements or alternatives to opioid use. Additionally, alternative methods like yoga, special diets, and food supplements provide diverse options for managing pain. Psychological therapies, including cognitive-behavioral techniques and mindfulness, address the mental and emotional dimensions of pain. Emerging technologies, including artificial intelligence, hold promise for optimizing pain management in terminal cancer care. This review explores advanced pain management strategies, focusing on traditional opioid therapies, modern pharmaceutical innovations, and non-pharmacological approaches such as alternative medicine, massage, dietary interventions, and psychological therapy.