Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

G.K. Mukusheva, Roza I. Jalmakhanbetova, Altynay Zh. Shaibek, Manshuk Nurmaganbetova, Aigerym R. Zhasymbekova, О. А. Нуркенов, Ekaterina A. Akishina, Irina A. Kolesnik, Evgenij A. Dikusar, Tatiana I. Terpinskaya

5 more authors

VLADIMIR A. KULCHITSKY, Vladimir Ivanovich Potkin, Alexander L. Pushkarchuk, Dmitry A. Lyakhov, Dominik Ludewig Michels

2024

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DOI 10.3390/molecules29143246
Data confidence 70 medium
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Abstract

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.