Relation between vitamin D and adolescents’ serum prolactin

Ainur Amanzholkyzy, Ainur Donayeva, Dinara Kulzhanova, Ibrahim Anwar Abdelazim, Talgar Abilov, Zhenisbek Baubekov, Ihab I. Samaha

2023

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.5114/pm.2023.133883
Data confidence 70 medium
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Abstract

Introduction: To detect whether there is a relation between vitamin D (Vit.D) and adolescents' serum prolactin (PRL) or not.Material and methods: Hundred and seventy-six adolescent girls were recruited for the current study, which was conducted in West Kazakhstan (Aktobe) over two years.After thorough evaluation, blood samples were taken from adolescents to measure thyroid stimulating hormone (TSH), free thyroxine (T4), PRL, glycosylated hemoglobin and 25(OH)D.The studied adolescents were classified into study group [25(OH)D deficient] and controls [normal 25(OH)D].The acquired adolescents' variables were analyzed using the Student t-test and Pearson's correlation.Results: The serum TSH and PRL were statistically higher in the study group than normal controls (3.73 ±1.45 mIU/ml and 47.5 ±7.6 ng/ml vs. 2.67 ±1.0 and 10.8 ±5.1, respectively), (p = 0.0003 and p = 0.0001, respectively).The free T4 was statistically lower in the study group than normal controls (1.4 ±0.6 ng/ml vs. 1.5 ±0.4), (p = 0.0001).Strong negative associations between the serum PRL and 25(OH)D [r = -0.803(p < 0.00001)], and between the serum PRL and free T4 [r = -0.6959(p < 0.00001)] were detected in this study.Additionally, there was a strong positive association between the serum PRL and TSH [r = 0.8137 (p < 0.00001)].Conclusions: A strong negative association between the serum PRL and 25(OH)D and a strong positive association between the serum PRL and TSH were detected in this study.This study recommends further studies to confirm the relation between Vit.D and PRL and screening Vit.D deficient adolescents for PRL and thyroid disorders.Key words: 25(OH)D, prolactin (PRL), thyroid disorders.hypothyroidism had deficient Vit.D compared to 20.6% of healthy controls [10].Appunni et al. also reported increased odds of hypothyroidism among Vit.D deficient participants [10].The relation between Vit.D and PRL are conflicting in the previous studies.Although, Saki et al. found the PRL was more potent in increasing the serum 1.25(OH) 2 D than estrogen in animal model [11], and Törnquist et al. found the PRL secretion increased from the animal cells incubated with 1.25(OH) 2 D [12].Haug et al. found the treatment of animal cells with 1.25(OH) 2 D caused an inhibition on PRL secretion [13].The 25(OH)D is the most extensively used biomarker to measure the serum Vit.D [14].Therefore, this cross-section research designed to detect whether there is a relation between Vit.D and adolescents' serum PRL or not. Material and methodsHundred and seventy-six (176) school attendant adolescent girls were recruited for this cross-sectional