Synthesis, Structure Characterization, and Antimicrobial Activity of 2-Amino-3-[(2-Amino-2-Carboxyethyl) Disulfanyl] Propanoic Acid Dihydrogen Triiodide Coordination Compound

Seitzhan Turganbay, Alexandr Ilin, Н.М. АТАГЕЛЬДИЕВА, Ardak B. Jumagaziyeva, Sabina T. Kenesheva, Gulshat Baigaipova, Sofia Mun

2023

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DOI 10.30919/es956
Data confidence 70 medium
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Abstract

The aim of this study was the synthesis of iodine coordination compounds for the treatment of nosocomial infections caused by drug-resistant bacteria.A new 2-amino-3-[(2-amino-2carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide coordination compound was synthesized in basic and water media with a stoichiometric ratio of 1:2:2 of Cystine:LiI:iodine.The physico-chemical properties of complex 2-amino-3-[(2-amino-2-carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide were examined.Obtained crystals were studied by singlecrystal X-ray diffraction, FTIR spectroscopy, UV-Vis spectrophotometer and Thermogravimetry/Differential Scanning Colorimeter (TG/DSC).The compound crystallizes in the orthorhombic P212121 with lattice parameters a = 9.5739(19) Å, b = 13.558(3)Å, c = 16.405(3)Å, α = 90, β = 90, 𝛾 = 90, V = 2129.4(7)Å 3 ; Z = 4.The antimicrobial activity of the synthesized compound was investigated.Activity evaluations were done against ATCC bacterial and clinical isolates, including WHO-prioritised drug-resistant strains.In the study, the effectiveness of a new coordination compound of iodine against bacteria with multidrug resistance was shown.This fact, as well as the semi-organic nature of the compound, determine the prospects for its use in medicine as an antimicrobial agent.